- Emmett Till and Mamie Till- Mobley House 6427 South Street Lawrence Avenue · built 1895 · designated January 27, 2021 Houses Woodlawn
- Halsted-Willow Group Four buildings located at the intersection of North Halsted and West Willow Streets, including 1727-1729 North Halsted, 1733 North Halsted, 1730-1732 North Halsted / 807 West Willow, and 1800 North Halsted · designated August 5, 2021 Offices and commercial buildings
- Illinois Bell Building Ameritech Building 225 W. Randolph Street · built 1966 · Holabird & Root · designated January 27, 2021 Offices and commercial buildings Loop
- Miracle House 2001 N. Nordica Avenue · built 1954 · Belli & Belli Architects and Engineers, Inc. · designated April 21, 2021 Houses Austin
- Monastery of the Holy Cross Buildings Immaculate Conception Parish Church, Immaculate Conception Roman Catholic Church, Church of the Immaculate Conception and Rectory 3101-3111 S. Aberdeen Street · built 1901 (Rectory); 1908-1909 (Church) · Hermann J. Gaul · designated October 14, 2021 Places of worship Bridgeport
- Morton Salt Company Warehouse Complex 1305-1399 North Elston Ave;1201299 W. Blackhawk Street · built 1930 · Graham, Anderson, Probst & White · designated June 25, 2021 Factories and warehouses West Town
- Muddy Waters House 4339 South Lake Park Avenue · built 1891 · designated October 14, 2021 Houses Kenwood
- Pentecostal Church of Holiness Our Lady of Lourdes Catholic Church 4208 W. 15th Street · built 1931-1932 · Louis Guenzel · designated May 26, 2021 Places of worship North Lawndale
- Perkins-Nordine House 6106 N. Kenmore Avenue · built 1902-1903 · Pond and Pond · designated January 27, 2021 Houses Edgewater
- Schlitz Brewery-Tied House, 1393-1399 W. Lake St. (Former) 1393-1399 W. Lake Street · built 1892 · designated September 14, 2021 Taverns and breweries Near West Side